A meta-analysis of the efficacy and toxicity of combining disease-modifying anti-rheumatic drugs in rheumatoid arthritis based on patient withdrawal.

@article{Choy2005AMO,
  title={A meta-analysis of the efficacy and toxicity of combining disease-modifying anti-rheumatic drugs in rheumatoid arthritis based on patient withdrawal.},
  author={Ernest H. S. Choy and Crystal Smith and Caroline J. Dor{\'e} and David Lloyd Scott},
  journal={Rheumatology},
  year={2005},
  volume={44 11},
  pages={1414-21}
}
INTRODUCTION Combinations of disease-modifying anti-rheumatic drugs (DMARDs) are increasingly used to treat rheumatoid arthritis (RA). Early trials showed their toxicity while recent trials suggest superior efficacy. Trials of DMARD combinations have enrolled different types of patient (early or established RA), used different designs (step-up, parallel or step-down) and utilized a range of outcome measures. We undertook a systematic review of combination DMARD therapy for RA and carried out a… CONTINUE READING
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