A meta-analysis of the effect of hormone replacement therapy upon depressed mood

@article{Zweifel1997AMO,
  title={A meta-analysis of the effect of hormone replacement therapy upon depressed mood},
  author={Julianne E Zweifel and William H. O'brien},
  journal={Psychoneuroendocrinology},
  year={1997},
  volume={22},
  pages={189-212}
}

Mood scores in relation to hormone replacement therapies during menopause: a prospective randomized trial.

Continuous combined hormone replacement regimens, CEE + MPA and tibolone, have superior long-term effects on mood scores in menopause and should be considered during the decision process for use of HRT due to menopausal symptoms.

Estrogen therapy for depression in postmenopausal women

EFFICACY OF ESTRADIOL IN PERIMENOPAUSAL DEPRESSION: SO MUCH PROMISE AND SO FEW ANSWERS

Methodologic differences of note include menopausal state (perimenopause vs. postmenopause), determination of state (earlier studies used age as a proxy measure), baseline symptomatology (asymptomatic vs. depressive symptoms vs. syndromic depression), route of hormone administration (transdermal vs. oral), and symptom or syndrome measure.

Hormone therapy and mood in perimenopausal and postmenopausal women: a narrative review

Hormone therapy may contribute to alleviating menopause-related depressive symptoms and should be specifically individualized in cases of more severe depressive conditions, and a combination of antidepressant and hormone therapy should be considered.

The other side of estrogen replacement therapy: Outcome study results of mood improvement in estrogen users and nonusers

  • K. Miller
  • Psychology
    Current psychiatry reports
  • 2003
There appears to be moderate evidence that HRT facilitates the improvement of clinical depression and the efficacy of antidepressants, and there is a clear need to examine the necessary duration of HRT for neuroprotection to decrease a woman’s risk for depression, cognitive dysfunction, and development of Alzheimer's disease.

Hormone therapy does not affect depression severity in older women.

  • K. GoldsteinL. Harpole L. Bastian
  • Psychology, Medicine
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
  • 2005
There was no evidence to suggest that women HT users differ from non-HT users in depressive symptom severity, and the role of estrogen in the etiology and treatment of depression in older women remains unclear.

A comparison of the effect of estrogen with or without progesterone on mood and physical symptoms in postmenopausal women.

It is suggested that for most postmenopausal women, the use of hormones will not be associated with clinically significant changes in mood or physical symptoms, which weighs favorably into the cost-benefit ratio for women considering hormone replacement therapy.
...

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