A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk.

  title={A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk.},
  author={Sarah Jayne Lewis and Stanley Zammit and D Gunnell and George Davey Smith},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  volume={135B 1},
Epigenetic mechanisms such as methylation of DNA, could lead to abnormal neurodevelopment and may be important in the etiology of schizophrenia. Maternal dietary folate intake may play a role in determining methylation levels. The MTHFR gene C677T polymorphism influences folate metabolism and intracellular availability of folate metabolites for methylation. We carried out a meta-analysis of MTHFR C677T genotype and schizophrenia risk, and found that TT homozygotes had a significantly increased… CONTINUE READING

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