A meta-analysis of structural brain abnormalities in PTSD

@article{Karl2006AMO,
  title={A meta-analysis of structural brain abnormalities in PTSD},
  author={Anke Karl and Michael Schaefer and Loretta S. Malta and Denise D{\"o}rfel and Nicolas Rohleder and Annett Werner},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2006},
  volume={30},
  pages={1004-1031}
}
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References

SHOWING 1-10 OF 137 REFERENCES
Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis.
Hippocampal volume in adult burn patients with and without posttraumatic stress disorder.
TLDR
Evidence is provided that smaller hippocampal size in trauma-exposed individuals is a result of traumatic stress, and the posttraumatic application of NMDA antagonists may protect against hippocampal damage induced by traumatic stressors but increases the patient's risk of developing PTSD symptoms.
Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder
Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder
MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder.
TLDR
A smaller right hippocampal volume in PTSD that is associated with functional deficits in verbal memory is consistent with high levels of cortisol associated with stress.
Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD.
TLDR
Smaller hippocampal volume is not a necessary risk factor for developing PTSD and does not occur within 6 months of expressing the disorder.
Bilateral hippocampal volume reduction in adults with post‐traumatic stress disorder: A meta‐analysis of structural MRI studies
TLDR
Volume differences are consistent with the notion that exposure to stressful experiences can lead to hippocampal atrophy, although prospective studies would be necessary to unambiguously establish such a relationship.
Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder
Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
TLDR
In monozygotic twins discordant for trauma exposure, it is found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology.
Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder
...
1
2
3
4
5
...