A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy

@article{Hu2011AMO,
  title={A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy},
  author={Xiaowei Hu and Juan Wang and Wanli Dong and Qi Fang and Lifang Hu and Chunfeng Liu},
  journal={Epilepsy Research},
  year={2011},
  volume={97},
  pages={73-82}
}
PURPOSE To conduct a meta-analysis to quantify whether valproate (VPA) is associated with an increased risk of polycystic ovary syndrome (PCOS) in women with epilepsy. METHODS A comprehensive literature search for all published studies of MEDLINE and EMBASE was performed for English language studies published from 1st January 1990 to 4th February 2011. The studies included should be prospective and controlled. We then performed a meta-analysis to identify polycystic ovary syndrome in women… Expand
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Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women
TLDR
The results of this study suggest that the manifestation of PCOS in women with focal epilepsy is not related to the administration of valproate or carbamazepine. Expand
Altered ovarian function and cardiovascular risk factors in valproate-treated women.
TLDR
The obese valproate-treated women with polycystic ovaries or hyperandrogenism, or both, had hyperinsulinemia and associated unfavorable changes in serum lipid levels consistent with insulin resistance. Expand
Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy.
TLDR
Menstrual disturbances, polycystic ovaries, and hyperandrogenism are often encountered in women taking valproate for epilepsy. Expand
Polycystic Ovaries and Hyperandrogenism in Women Taking Valproate for Epilepsy
TLDR
This Finland study studied 238 women with epilepsy who were seen regularly at the Outpatient Department of the University Hospital, Oulu, Finland and found that menstrual disturbances were present in 13 of the women receiving valproate alone. Expand
Obesity and endocrine disorders in women taking valproate for epilepsy
TLDR
The weight gain can be progressive, and is associated with hyperinsulinemia and low serum levels of insulin‐like growth factor‐binding protein 1, which may lead to hyperandrogenism and polycystic ovaries. Expand
Long-Term Effects of Valproic Acid on Reproductive Endocrine Functions in Turkish Women with Epilepsy
TLDR
No statistically significant dose or duration-related rise of risk for patients who developed PCOS and menstrual irregularities and those who were not on long-term VPA therapy support the hypothesis of early occurring VPA-associated metabolic and endocrine changes. Expand
Predictors of ovulatory failure in women with epilepsy
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Women with epilepsy are more likely to experience anovulatory menstrual cycles and the effects of epilepsy syndrome, and AED therapy may be additive, and clinicians must be alert to this potential complication of epilepsy. Expand
Valproic acid fails to induce polycystic ovary syndrome in female rats
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TLDR
It appears that the rat has limited usefulness for modeling VPA-induced symptoms associated with PCOS, as VPA and DVS treatment were associated with a higher proportion of animals developing cystic follicles but did not mimic the Vpa-induced PCOS that is observed in women. Expand
Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy
TLDR
Lamotrigine monotherapy may be more appropriate than valproate for women in whom reproductive endocrine or metabolic abnormalities are potential concerns, i.e. women with concerns about weight gain, diabetes, hirsutism, polycystic ovary syndrome, menstrual dysfunction or infertility. Expand
Reproductive endocrine function in women with epilepsy: The role of epilepsy type and medication
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Both idiopathic generalized epilepsy and valproate were associated with an increased risk of reproductive endocrine disorders in WWE in this post hoc reanalysis of data on a large number of WWE subjects. Expand
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