A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy

  title={A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy},
  author={Xiaowei Hu and Juan Wang and Wanli Dong and Qi Fang and Lifang Hu and Chunfeng Liu},
  journal={Epilepsy Research},

Figures and Tables from this paper

A Meta-Analysis of PCOS-Related Reproductive Abnormalities in Women Taking Valproate for Epilepsy

VPA chronic medication lead to higher risk of developing PCOS, PCO, hyperandrogenism and menstrual disorder in women with epilepsy.

Reproductive and metabolic abnormalities in women taking valproate for bipolar disorder: a meta-analysis.

Endocrine reproductive dysfunctions in women with epilepsy on antiepileptic therapy

The endocrine - reproductive dysfunctions occurred more frequently in epileptic women treated with valproate; these endocrine abnormalities may have a negative impact on fertility in women with epilepsy and therefore young patients should be screened and carefully evaluated in an endocrinology service prior to start the anti- epileptic treatment.

Polycystic ovary syndrome in patients on antiepileptic drugs

The study observed significantly higher occurrence of PCO in patients on VPA compared to other AEDs and the normal population, and VPA group (Epilepsy + BPAD) had a significantlyHigher occurrence of obesity than other treatment groups.

Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis

Polycystic ovary syndrome (PCOS), a reproductive endocrine system disease, is a complication that women with epilepsy are susceptible to, and its total prevalence is 8%–13% in the female population and sometimes as high as 26% in female epilepsy patients.


Long–term administration of valproate in women with bipolar disorder or epilepsy is believed to result in the increased risk of hyperandrogenism, menstrual abnormalities and polycystic ovaries, and Valproate may also increase the risk of infertility and other associated symptoms ofpolycystic ovarian syndrome.

Fertility treatment with clomiphene citrate and childhood epilepsy: a nationwide cohort study.

The increased risk of focal epilepsy may be related to the hormonal treatment, since the association tended to increase with increasing cumulative dosage of clomiphene citrate prior to conception, and the association persisted in a sibling analysis.

Can Polycystic Ovarian Syndrome be cured? Unfolding the Concept of Secondary Polycystic Ovarian Syndrome!

  • S. Khadilkar
  • Medicine, Biology
    The Journal of Obstetrics and Gynecology of India
  • 2019
The clinical categorization by HA-PODS nomenclature of both primary and secondary PCOS can minimize diagnostic and therapeutic pitfalls and will serve as a checklist to ensure the appropriate investigation is ordered and specific treatment is initiated as per diagnostic code.

Endocrinopathies and other disorders inducing a polycystic ovary syndrome phenotype.

Although PCOS in the short-term is regarded as a 'benign' disease, a proportion of patients may harbor other underlying disorders that can be life-threatening, requiring prompt diagnosis and treatment.

Decreased Serum Level of Gamma-amino Butyric Acid in Egyptian Infertile Females with Polycystic Ovary Syndrome is Correlated with Dyslipidemia, Total Testosterone and 25(OH) Vitamin D Levels

It is suggested that disrupted GABA level in the peripheral circulation is an additional contributing factor to PCOS manifestations and further investigations for GABA adjustment might provide a promising means for better management of PCOS symptoms.



Polycystic Ovaries and Hyperandrogenism in Women Taking Valproate for Epilepsy

This Finland study studied 238 women with epilepsy who were seen regularly at the Outpatient Department of the University Hospital, Oulu, Finland and found that menstrual disturbances were present in 13 of the women receiving valproate alone.

Obesity and endocrine disorders in women taking valproate for epilepsy

The weight gain can be progressive, and is associated with hyperinsulinemia and low serum levels of insulin‐like growth factor‐binding protein 1, which may lead to hyperandrogenism and polycystic ovaries.

Long-Term Effects of Valproic Acid on Reproductive Endocrine Functions in Turkish Women with Epilepsy

No statistically significant dose or duration-related rise of risk for patients who developed PCOS and menstrual irregularities and those who were not on long-term VPA therapy support the hypothesis of early occurring VPA-associated metabolic and endocrine changes.

Predictors of ovulatory failure in women with epilepsy

Women with epilepsy are more likely to experience anovulatory menstrual cycles and the effects of epilepsy syndrome, and AED therapy may be additive, and clinicians must be alert to this potential complication of epilepsy.

Valproic acid fails to induce polycystic ovary syndrome in female rats

  • D. LagaceM. Nachtigal
  • Biology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2003

Characterization of reproductive endocrine disorders in women with epilepsy.

The results of this study suggest that the prevalence of disordered ovulation, in particular polycystic ovary syndrome, is increased in epilepsy, independent of antiepileptic medications or type of seizure disorder.