A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity

@article{Gonzales2007AMO,
  title={A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity},
  author={Denise Gonzales and Kelly J. Norsworthy and Steven J. Kern and Steve Banks and Pamela C. Sieving and Robert A Star and C Natanson and Robert L Danner},
  journal={BMC Medicine},
  year={2007},
  volume={5},
  pages={32 - 32}
}
BACKGROUND Meta-analyses of N-acetylcysteine (NAC) for preventing contrast-induced nephrotoxicity (CIN) have led to disparate conclusions. Here we examine and attempt to resolve the heterogeneity evident among these trials. METHODS Two reviewers independently extracted and graded the data. Limiting studies to randomized, controlled trials with adequate outcome data yielded 22 reports with 2746 patients. RESULTS Significant heterogeneity was detected among these trials (I2 = 37%; p = 0.04… CONTINUE READING
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