A meta-analysis for the role of proton pump inhibitor therapy in patients with laryngopharyngeal reflux

@article{Wei2016AMF,
  title={A meta-analysis for the role of proton pump inhibitor therapy in patients with laryngopharyngeal reflux},
  author={Chun-hua Wei},
  journal={European Archives of Oto-Rhino-Laryngology},
  year={2016},
  volume={273},
  pages={3795-3801}
}
  • Chun-hua Wei
  • Published 2016
  • Medicine
  • European Archives of Oto-Rhino-Laryngology
We aimed to systematically review the randomized controlled trials (RCTs) regarding the therapeutic efficiency of proton pump inhibitor (PPI) therapy for laryngopharyngeal reflux (LPR). Randomized and placebo-controlled trials regarding the therapeutic efficacy of PPIs on LPR patients were systematically searched from MEDLINE, Cochrane Library, and EMBASE. Data were extracted from eligible studies meeting the inclusion criteria. Heterogeneity among these eligible studies was evaluated by the Q… Expand
Proton Pump Inhibitors for the Treatment of Laryngopharyngeal Reflux. A Systematic Review.
TLDR
Six out of the nine systematic reviews/meta-analyses concluded that PPI therapy is not superior to placebo and three concluded thatPPI therapy significantly improved LPR symptoms although they did not identify any difference in the post-treatment laryngoscopic findings. Expand
A Prospective Randomized Clinical Trial of Combination Therapy with Proton Pump Inhibitors and Mucolytics in Patients with Laryngopharyngeal Reflux
TLDR
Combination therapy with mucolytics and PPI compared to PPI alone did not lead to faster or more effective symptomatic relief in LPR patients. Expand
Therapeutic trial of proton pump inhibitors for management of patients with laryngopharyngeal reflux
TLDR
Therapeutic trial seems to be an effective way of initial management of patients with anticipated LPR which can be used after the cause of the problems is ruled out by other specialists. Expand
Alternatives to Acid Suppression Treatment for Laryngopharyngeal Reflux
TLDR
Mixed evidence with a high degree of bias and heterogeneity between studies for the modalities presented in the paper means an anti-reflux diet is recommended for all patients and there is some low-quality evidence to support alkaline water. Expand
Effective and safe proton pump inhibitor therapy in acid-related diseases – A position paper addressing benefits and potential harms of acid suppression
TLDR
Overall, PPIs are irreplaceable drugs in the management of acid-related diseases, however, PPI treatment, as any kind of drug therapy, is not without risk of adverse effects. Expand
The effect of baclofen combined with a proton pump inhibitor in patients with refractory laryngopharyngeal reflux: A prospective, open‐label study in thirty‐two patients
TLDR
Evaluated the efficacy of baclofen in patients with refractory LPR confirmed using 24‐hour multichannel intraluminal impedance‐pH (MII‐ pH) monitoring to find a new target for PPI‐resistant GERD. Expand
Reflux finding score and reflux symptom index as potential predictors for proton pump inhibitor response in globus pharyngeus patients: A prospective study.
TLDR
Both together, as well individually, pre-treatment RSI and RFS ratings can help predict treatment response of empirical PPI treatment in patients experiencing globus pharyngeus symptoms. Expand
Lansoprazole for persistent throat symptoms in secondary care: the TOPPITS RCT.
TLDR
To assess the value of proton pump inhibitor therapy in patients with persistent throat symptoms, a double-blind, placebo-controlled, randomised Phase III trial in eight UK ear, nose and throat departments was conducted. Expand
Gaviscon® Advance alone versus co-prescription of Gaviscon® Advance and proton pump inhibitors in the treatment of laryngopharyngeal reflux
TLDR
Gaviscon® Advance alone is effective in treating symptoms of LPR, while co-prescription with a high-dose PPI offers no additional benefit. Expand
Assessment and Diagnostic Accuracy Evaluation of the Reflux Symptom Index (RSI) Scale: Psychometric Properties using Optimal Scaling Techniques
TLDR
It would be necessary to think about modifying the original RSI in order to improve its sensitivity and specificity (RSI binary version, adding or changing some items), or to introduce new scores in to better frame the probably affected of LPR patient. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 28 REFERENCES
Rabeprazole is effective in treating laryngopharyngeal reflux in a randomized placebo-controlled trial.
  • P. Lam, M. Ng, +5 authors B. Wong
  • Medicine
  • Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2010
TLDR
Twelve weeks of treatment with rabeprazole (20 mg, twice daily) significantly improved reflux symptoms, compared with placebo, in patients with LPR, indicating the requirement for longer treatment duration in patientsWith LPR. Expand
Double-blind, placebo-controlled trial with esomeprazole for symptoms and signs associated with laryngopharyngeal reflux
TLDR
In the treatment of LPR-related symptoms a high placebo effect can be observed, but compared to control, twice-daily PPI treatment for three months demonstrated a significantly greater improvement in laryngeal appearance and LPR symptoms. Expand
Proton Pump Inhibitor Therapy for Chronic Laryngo-Pharyngitis: A Randomized Placebo-Control Trial
  • D. Steward, K. Wilson, +4 authors J. Welge
  • Medicine
  • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2004
TLDR
Compared to baseline, lifestyle modification for 2 months significantly improved chronic laryngo-pharyngitis symptoms and lifestyle modification compliance correlated significantly with global improvement. Expand
Proton Pump Inhibitors Versus Solitary Lifestyle Modification in Management of Laryngopharyngeal Reflux and Evaluating Who is at Risk: Scenario in a Developing Country
TLDR
The study establishes the need for continuing lifestyle modification further for at least six months after the cessation of proton pump inhibitor therapy to prevent early recurrence of symptoms and indicates the probable protocol to be followed prior to considering further investigation. Expand
[The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].
TLDR
PPI therapy could significantly alleviate the hoarseness symptom in LPR patients. Expand
Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial
TLDR
Empirical treatment with lansoprazole is efficacious in relieving symptoms of laryngeal symptoms compared to placebo and can be considered as a first-line option in managing patients with idiopathic chronic laryngitis. Expand
Double-Blind, Placebo-Controlled Trial with Single-Dose Pantoprazole for Laryngopharyngeal Reflux
TLDR
Response was similar between single-dose pantoprazole and placebo in newly diagnosed LPR, and results suggested that laryngeal exam was not useful in following treatment response. Expand
A prospective evaluation of esophageal testing and a double-blind, randomized study of omeprazole in a diagnostic and therapeutic algorithm for chronic cough
TLDR
It is suggested that the best diagnostic and therapeutic approach, after excluding asthma and postnasal drip syndrome, is empiric treatment for 2 wk with a high dose proton pump inhibitor. Expand
Effect of Pantoprazole on the Course of Reflux-Associated Laryngitis: a Placebo-Controlled Double-Blind Crossover Study
TLDR
The self-limited nature of reflux-associated laryngitis in non-smokers is largely underestimated and pantoprazole may be helpful especially in relieving acute symptoms, but the advantage of long-term treatment over placebo has been greatly overestimated. Expand
Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-hour pH monitoring
TLDR
In a considerable number of patients with suspected LPR, pH monitoring reveals no abnormal proximal reflux, and esomeprazole 40 mg every day together with lifestyle modifications could reach adequate acid suppression in a large number of Patients. Expand
...
1
2
3
...