A meta‐analysis of the association between Caesarean section and childhood asthma

@article{Thavagnanam2008AMO,
  title={A meta‐analysis of the association between Caesarean section and childhood asthma},
  author={Surendran Thavagnanam and John Fleming and Ann Bromley and Mike D Shields and Chris R. Cardwell},
  journal={Clinical \& Experimental Allergy},
  year={2008},
  volume={38}
}
Background Children born by Caesarean section have modified intestinal bacterial colonization and consequently may have an increased risk of developing asthma under the hygiene hypothesis. The results of previous studies that have investigated the association between Caesarean section and asthma have been conflicting. 
View on Wiley
ncbi.nlm.nih.gov
595 Citations
Highly Influential Citations
9
Background Citations
146
Methods Citations
6
Results Citations
15

595 Citations

The impact of birth mode of delivery on childhood asthma and allergic diseases–a sibling study

Caesarean section (CS) has been reported to increase the risk of asthma in offspring. This may be due to that infants delivered by CS are unexposed to vaginal flora, according to the ‘hygiene…

Caesarean Section has no impact on lung function at the age of 15 years

A large number of studies have shown an increased risk of childhood asthma for children born by Caesarean Section, and some suggest this risk may be higher than in children born without a Cesarean section.

Cesarean section and risk of allergies in Ecuadorian children: A cross‐sectional study

An association between cesarean section and increased prevalence of childhood allergic diseases and these observations have been consistent in industrialized countries while evidence from developing countries is limited.

Caesarean section and allergic manifestations: insufficient evidence of association found in population‐based study of children aged 1 to 4 years

To provide evidence on the association between caesarean section and allergic manifestations in an unselected child population, a large sample of children from around the world were selected for research.

Delivery mode and the incidence of atopic sensitization and food allergy in a Finnish child population

    K. PyrhönenP. Kulmala
    Medicine, Biology
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2021
Caesarean section (CS) has been associated with an increased risk of subsequent atopic diseases, particularly asthma and respiratory allergies, but controversial findings have also been reported. Our…

Conception via in vitro fertilization and delivery by Caesarean section are associated with paediatric asthma incidence

Evidence of a correlation between asthma, conception via in vitro fertilization (IVF) and delivery through Caesarean section (C‐section) is inconclusive.

Delivery by caesarean section and childhood cancer: a nationwide follow‐up study in three countries

To investigate the association between delivery by caesarean section and risk of childhood cancer, a large number of women were given a Caesareans during pregnancy to reduce the chance of developing childhood cancer.

Forceps birth delivery, allergic sensitisation and asthma: a population‐based cohort study

    R. HancoxC. LandhuisM. Sears
    Medicine, Biology
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2013
Studies indicate an increased risk of allergies among children born by caesarean section, possibly because immune development is altered by avoiding exposure to maternal vaginal flora. It is unknown…

Time to consider the risks of caesarean delivery for long term child health

The evidence linking caesarean delivery with childhood chronic disease and guidelines on delivery should be reviewed with these risks in mind are examined.

Atopic dermatitis is associated with Caesarean sections in Korean adolescents, but asthma is not

The relationship between mode of delivery and atopic dermatitis and asthma in Korean adolescents and research has rarely been conducted in Asian countries such as South Korea.
...

40 References

Caesarean section increases the risk of hospital care in childhood for asthma and gastroenteritis

    S. HåkanssonK. Källén
    Medicine, Political Science
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2003
Objective To investigate if caesarean section (CS) increases the risk for childhood asthma and gastroenteritis with reference made to children born with vaginal delivery (VD).

Caesarean section delivery and the risk of allergic disorders in childhood

Beneficial intestinal microbes originate from the maternal vaginal tract and thus are more likely to be transferred during vaginal births than during Caesarean sections, and may increase the susceptibility to allergic disorders in young children.

Mode of delivery is not associated with asthma or atopy in childhood

Background Caesarean‐section delivery has been associated with the subsequent development of atopy and wheezing in childhood and the need for further research is needed to establish a cause-and-effect relationship.

Perinatal characteristics and obstetric complications as risk factors for asthma, allergy and eczema at the age of 6 years

    R. M. D. BernsenJ. C. De JongsteB. KoesH. A. AardoomJ. C. van der Wouden
    Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2005
A large number of studies have evaluated the role of fetal development and obstetric complications, but the results are not unequivocal.

Caesarean section and risk of asthma and allergy in adulthood.

Caesarean section had a strong effect on current doctor-diagnosed asthma in adulthood with an adjusted odds ratio (OR) of 3.23 (95% CI 1.53, 6.80), but no substantial effects were observed for atopy, hay fever, and atopic eczema.

Mode of delivery and risk of developing allergic disease.

There is no convincing evidence to suggest that babies born by caesarean, forceps, or breech delivery had an increased risk of developing allergic disease.

In utero and perinatal complications preceding asthma

Background: It has been suggested that pregnancy and early life may influence the development of asthma in the offspring, but published studies have not carefully controlled for potential biases.

Perinatal risk factors for sensitization, atopic dermatitis and wheezing during the first year of life (PIPO study)

The influence of perinatal environmental factors on early sensitization, atopic dermatitis and wheezing during the first year of life is evaluated.

Childhood asthma hospitalization risk after cesarean delivery in former term and premature infants.

Obstetric Complications and Asthma in Childhood

The results encourage further evaluation of the association between obstetric complications and risk of asthma among children in other populations, and further exploration of possible mechanisms underlying the association.