A meta‐analysis of association studies between the 10‐repeat allele of a VNTR polymorphism in the 3′‐UTR of dopamine transporter gene and attention deficit hyperactivity disorder

@article{Yang2007AMO,
  title={A meta‐analysis of association studies between the 10‐repeat allele of a VNTR polymorphism in the 3′‐UTR of dopamine transporter gene and attention deficit hyperactivity disorder},
  author={Binrang Yang and Raymond C.K. Chan and Jin Jing and Tao Li and Pak Chung Sham and Ronald Chen},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2007},
  volume={144B}
}
The association between the 10‐repeat allele of the dopamine transporter gene (DAT) and attention deficit hyperactivity disorder (ADHD) is uncertain. This study aimed to conduct a meta‐analysis of the association between the 10‐repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3′‐untranslated region (UTR) of the DAT1 gene and ADHD. We pooled up 18 published transmission disequilibrium test (TDT) studies between the 40‐base pair VNTR polymorphism in the3′‐UTR of the… 

Association study and a systematic meta-analysis of the VNTR polymorphism in the 3′-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder

TLDR
Further indication is found for a possible DAT1 gene involvement in attention-deficit hyperactivity disorder, however, further studies should be conducted with stringent phenotyping to reduce heterogeneity, a limitation observed in most included studies.

A common haplotype at the dopamine transporter gene 5′ region is associated with attention‐deficit/hyperactivity disorder

  • J. GenroG. Polanczyk M. Hutz
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
A role for the promoter region in ADHD susceptibility is suggested and that allele heterogeneity should be highly considered in DAT1 gene association studies highlighting the importance of this gene in the genetics of the disorder.

Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder

TLDR
The finding suggests that genetic variation in the promoter region of DAT1 may be a risk factor in the development of ADHD.

Lack of association of the dopamine transporter gene in a French ADHD sample

  • M. WohlC. Boni D. Purper-Ouakil
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
Analysis of a sample of 146 ADHD children and their parents with a transmission disequilibrium test (TDT) design, assessing age, inattention, and hyperactivity dimensions and total score of the ADHD Rating Scale and PBAT analyses showed no role of this polymorphism for any of the studied endophenotypes.

Association of the dopamine transporter (SLC6A3/DAT1) gene 9–6 haplotype with adult ADHD

  • B. FrankeM. Hoogman J. Buitelaar
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
It is found that age is an important factor to be taken into account when assessing the association of SLC6A3 with ADHD in adults, and the differential association of the gene in children and in adults might imply that SLC 6A3 plays a role in modulating the ADHD phenotype, rather than causing it.

Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: Developmental continuities in gene–environment interplay

TLDR
The results provide evidence for developmental continuities in G x E interaction, explain some of the heterogeneity in ADHD outcomes following institutional deprivation and add to the understanding of environmental determinants of sADHD.

Role of gene–gene/gene–environment interaction in the etiology of eastern Indian ADHD probands

No relationship between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and schizophrenia: a meta-analysis of family-based association studies

TLDR
A meta-analysis of family-based studies was performed to explore the role of Ser9Gly in the etiology of schizophrenia and found no association between DRD3 gene Ser 9Gly polymorphism and the risk of schizophrenia.

ADHD and DAT1: Further evidence of paternal over‐transmission of risk alleles and haplotype

  • Z. HawiL. Kent M. Gill
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2010
TLDR
The IMAGE sample, the largest of the three‐replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele of DAT1 and a similar pattern of over‐transmission of paternal risk haplotypes (constructed from the above alleles) was observed.

Genetic associations between ADHD and dopaminergic genes (DAT1 and DRD4) VNTRs in Korean children

TLDR
The results suggest that DAT1 VN TRs and DRD4 VNTRs play a role in the genetic etiology of ADHD in Korean children.
...

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