A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes

@article{Carbone2007AME,
  title={A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes},
  author={Michele Carbone and Salih Kahraman Ahmet Emri and Ahmet Umran Dogan and Ian Steele and Murat A Tuncer and Harvey I. Pass and Yusuf Izzettin Bariş},
  journal={Nature Reviews Cancer},
  year={2007},
  volume={7},
  pages={147-154}
}
In Cappadocia, Turkey, an unprecedented mesothelioma epidemic causes 50% of all deaths in three small villages. Initially linked solely to the exposure to a fibrous mineral, erionite, recent studies by scientists from Turkey and the United States have shown that erionite causes mesothelioma mostly in families that are genetically predisposed to mineral fibre carcinogenesis. This manuscript reports, through the eyes of one of the researchers, the resulting scientific advances that have come from… Expand
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References

SHOWING 1-10 OF 87 REFERENCES
Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey
TLDR
Analysis of a six-generation extended pedigree of 526 individuals showed that mesothelioma was genetically transmitted, probably in an autosomal dominant way, and this finding should lead to preventive strategies to lower the incidence of mesot helioma in future generations. Expand
An outbreak of pleural mesothelioma and chronic fibrosing pleurisy in the village of Karain/Urgüp in Anatolia.
TLDR
The 575 inhabitants of the remote Anatolian village of Karain suffered 11 deaths from pleural mesothelioma in 1975/76 and there were five cases of fibrosing pleurisy, but inhabitants of the neighbouring villages are free of mesotelioma. Expand
Clinicians’ Approach to Mesothelioma
TLDR
The scientific basis guiding approaches of clinicians is discussed throughout this book and the specific clinical manifestations of the common types of MM are presented in this chapter and Chapters 24 and 25. Expand
Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey.
Malignant mesothelioma in the western world is often associated with asbestos exposure. It is a relatively rare cancer that causes approximately 2,500 deaths yearly in the United States and 1,000Expand
Erionite exposure and mesotheliomas in rats.
TLDR
Experimental studies using both intrapleural inoculation and inhalation techniques with erionite from this region and from Oregon in the United States demonstrate that there is a valuable new fibre for experimental study and a possible hazard to man in regions other then Turkey. Expand
MALIGNANT MESOTHELIOMA AND RADIOLOGICAL CHEST ABNORMALITIES IN TWO VILLAGES IN CENTRAL TURKEY An Epidemiological and Environmental Investigation
A comparative epidemiological and environmental study in two neighbouring villages, Karain and Karlin, in Central Turkey showed an excess adult mortality, shortening of life expectancy, and an excessExpand
Environmentally-induced malignant pleural mesothelioma and HLA distribution in Turkey.
  • Y. Karakoca, S. Emri, +4 authors A. Sahin
  • Medicine
  • The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 1998
TLDR
The predictive role of the HLA antigens -B41, -B58 and -DR16 for MPM needs to be further investigated to help in screening the population at risk, and facilitate preventive measures such as family counselling and gene therapy. Expand
Diffuse Pleural Mesothelioma and Asbestos Exposure in the North Western Cape Province
TLDR
In a majority of cases of diffuse pleural mesothelioma, all but one have a probable exposure to crocidolite asbestos (Cape blue) in the Asbestos Hills which lie to the west of Kimberley in the north west of Cape Province. Expand
Malignant mesotheliomas in a small village in the Anatolian region of Turkey: an epidemiologic study.
TLDR
An epidemiologic and cause-related study was done in Tuzköy, a small village in the city of Nevşehir, in the Anatolian region of Turkey, where zeolite was thought to be the cause of malignant pleural mesothelioma and several other respiratory disorders. Expand
Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure.
TLDR
The hypothesis that individual susceptibility to MM can be modulated by the interaction between polymorphic genes involved in the metabolism and the intensity of asbestos exposure is strengthened. Expand
...
1
2
3
4
5
...