A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes

  title={A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes},
  author={Michele Carbone and Salih Kahraman Ahmet Emri and Ahmet Umran Dogan and Ian Steele and Murat A. Tuncer and Harvey I. Pass and Yusuf Izzettin Bariş},
  journal={Nature Reviews Cancer},
In Cappadocia, Turkey, an unprecedented mesothelioma epidemic causes 50% of all deaths in three small villages. Initially linked solely to the exposure to a fibrous mineral, erionite, recent studies by scientists from Turkey and the United States have shown that erionite causes mesothelioma mostly in families that are genetically predisposed to mineral fibre carcinogenesis. This manuscript reports, through the eyes of one of the researchers, the resulting scientific advances that have come from… 
The Cappadocia mesothelioma epidemic: its influence in Turkey and abroad.
  • S. Emri
  • Medicine
    Annals of translational medicine
  • 2017
A new, very active field of research developed following the discoveries to elucidate the mechanism by which BAP1 modulates mineral fiber carcinogenesis as well as to identify additional genes that when mutated increase the risk of mesothelioma and other environmentally related cancers.
Endemic Malignant Mesothelioma: Exposure to Erionite Is More Important Than Genetic Factors
ABSTRACT The village of Karain, Turkey, has the world's highest prevalence rate of malignant mesothelioma (MM). Environmental exposure to erionite is thought to cause the disease. However, it has
Malignant Peritoneal Mesothelioma
In developed countries, MPM is the most common peritoneal malignancy, with an estimated annual incidence of approximately 10,000 cases in China and the life expectancy of patients is restricted to be 4–12 months.
Familial mesothelioma in first degree relatives
Several reports of familial aggregations of mesothelioma strongly support that genetic factors in collaboration with environmental exposure may contribute etiologically to an as yet unknown fraction of occurrence of this disease.
Malignant Mesothelioma: Development to Therapy
Developmental mechanisms as well as current therapies available for MM are focused on, which would still take decades to eradicate this disease if asbestos was completely removed from the authors' lives today.
Mesothelioma: Scientific clues for prevention, diagnosis, and therapy
Novel immunohistochemical and molecular markers have improved the accuracy of diagnosis; however, about 14% (high‐resource countries) to 50% (developing countries) of mesothelioma diagnoses are incorrect, resulting in inadequate treatment and complicating epidemiological studies.
Pleural Mesothelioma in New Caledonia: Associations with Environmental Risk Factors
The ecological analyses identified serpentinite on roads as the greatest environmental risk factor for mesothelioma in New Caledonia and the use of whitewash, previously suggested to be a risk factor, was not associated with MM incidence.
The genetic susceptibility in the development of malignant pleural mesothelioma.
The susceptibility to develop MPM following asbestos exposure is modulated moderately by the individual genetic background, as for other types of sporadic cancers.
Clinical and Prognostic Features of Erionite-Induced Malignant Mesothelioma
Erionite has a higher degree of carcinogenicity with possible genetic transmission of erionite susceptibility in an autosomal dominant fashion andTherapeutic management for E-MPM remains very limited, and cure of the disease is extremely rare.
Malignant pleural mesothelioma: Current status and future projections in Turkey
It is presented that currently MPM is mostly due to environmental FME, but in the future, it is expected to diagnose higher occupational cases especially after 2015 till 2040.


Clinicians’ Approach to Mesothelioma
The scientific basis guiding approaches of clinicians is discussed throughout this book and the specific clinical manifestations of the common types of MM are presented in this chapter and Chapters 24 and 25.
Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey.
Malignant mesothelioma in the western world is often associated with asbestos exposure. It is a relatively rare cancer that causes approximately 2,500 deaths yearly in the United States and 1,000
Environmentally-induced malignant pleural mesothelioma and HLA distribution in Turkey.
  • Y. Karakoca, S. Emri, A. Sahin
  • Medicine
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 1998
The predictive role of the HLA antigens -B41, -B58 and -DR16 for MPM needs to be further investigated to help in screening the population at risk, and facilitate preventive measures such as family counselling and gene therapy.
Environmental fibrous zeolite (erionite) exposure and malignant tumors other than mesothelioma.
The hypothesis that erionite fibers cause cancer other than mesothelioma and lung cancer is supported, and mineralogic analyses of the tissues should be performed to demonstrate this relationship.
Chrysotile asbestos is the main cause of pleural mesothelioma.
Examination of all pertinent studies makes it clear that chrysotile asbestos is similar in potency to amphibole asbestos, and since asbestos is the major cause of mesothelioma, and chrysOTile constitutes 95% of all asbestos use world wide, it can be concluded that ch Chrysotilebestos is the main cause of pleural mesot Helioma in humans.
The History of Mesothelioma
The story of the discovery of this rare tumor and of the subsequent controversies that arose about its causation by specific forms of commercial asbestos is long and complex, and the focus has been on the viral contribution to pathogenesis such as SV40 and human genetics and treatment strategies.
Endemic pleural disease associated with exposure to mixed fibrous dust in Turkey.
Several different kinds of asbestos minerals in addition to erionite have now been found in environmental samples taken from the villages where these diseases occur.