A mesoporous silica nanoparticle--PEI--fusogenic peptide system for siRNA delivery in cancer therapy.

@article{Li2013AMS,
  title={A mesoporous silica nanoparticle--PEI--fusogenic peptide system for siRNA delivery in cancer therapy.},
  author={Xu Li and Yijie Chen and Mingqi Wang and Yong-jie Ma and Weiliang Xia and Hongchen Gu},
  journal={Biomaterials},
  year={2013},
  volume={34 4},
  pages={1391-401}
}
RNA interference (RNAi) is widely regarded as a promising technology for disease treatment, yet one major obstacle for its clinical application is the lack of efficient siRNA delivery vehicles. In this study, we described a magnetic mesoporous silica nanoparticles (M-MSNs)-based, polyelectrolyte (polyethylenimine, PEI) and fusogenic peptide (KALA)-functionalized siRNA delivery system (denoted as M-MSN_siRNA@PEI-KALA), which was highly effective for initiating target gene silencing both in vitro… CONTINUE READING
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