A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy.

@article{Miyata1998AMG,
  title={A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy.},
  author={Toshio Miyata and Masaomi Nangaku and Dai Suzuki and Reiko Inagi and Kazuhiro Uragami and Hiromichi Sakai and Kousaku Okubo and Kiyoshi Kurokawa},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={102 4},
  pages={
          828-36
        }
}
  • Toshio Miyata, Masaomi Nangaku, +5 authors Kiyoshi Kurokawa
  • Published 1998
  • Biology, Medicine
  • The Journal of clinical investigation
  • Mesangial cells play an important role in maintaining a structure and function of the glomerulus and in the pathogenesis of glomerular diseases. To identify a specific gene expressed in human mesangial cells, we used a rapid large-scale DNA sequencing and computerized data processing to compare the transcripts in cultured human mesangial cells with various different cells and organs. Using this novel approach, we discovered a new mesangium-predominant gene termed "megsin." We obtained a full… CONTINUE READING

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