A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy.

@article{Miyata1998AMG,
  title={A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy.},
  author={Toshio Miyata and Masaomi Nangaku and Daisuke Suzuki and Reiko Inagi and Kazuhiro Uragami and Hiromichi Sakai and Kousaku Okubo and Kiyoshi Kurokawa},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={102 4},
  pages={828-36}
}
Mesangial cells play an important role in maintaining a structure and function of the glomerulus and in the pathogenesis of glomerular diseases. To identify a specific gene expressed in human mesangial cells, we used a rapid large-scale DNA sequencing and computerized data processing to compare the transcripts in cultured human mesangial cells with various different cells and organs. Using this novel approach, we discovered a new mesangium-predominant gene termed "megsin." We obtained a full… CONTINUE READING
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