A memory for extracellular Ca2+ by speeding recovery of P2X receptors from desensitization.

@article{Cook1998AMF,
  title={A memory for extracellular Ca2+ by speeding recovery of P2X receptors from desensitization.},
  author={Sean Peter Cook and Karin D Rodland and Edwin W. McCleskey},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 22},
  pages={
          9238-44
        }
}
Nerve endings of nociceptors (pain-sensing neurons) express an unusual subtype of ATP-gated ion channel, the P2X3 receptor, that rapidly desensitizes (<100 msec) and slowly recovers (>20 min). Here we show that Ca2+, or certain other polyvalent cations, binds to an extracellular site on rat sensory neurons and can increase current through P2X3 channels more than 10-fold. Importantly, Ca2+ facilitates P2X3 current to precisely the same level whether a transient Ca2+ change occurred just before… CONTINUE READING
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