A membrane transport defect leads to a rapid attenuation of translation initiation in Saccharomyces cerevisiae.

@article{Deloche2004AMT,
  title={A membrane transport defect leads to a rapid attenuation of translation initiation in Saccharomyces cerevisiae.},
  author={Olivier Deloche and Jes{\'u}s de la Cruz and Dieter Kressler and Monique Do{\`e}re and Patrick Linder},
  journal={Molecular cell},
  year={2004},
  volume={13 3},
  pages={
          357-66
        }
}
Transport of lipids and proteins is a highly regulated process, which is required to maintain the integrity of various intracellular organelles in eukaryotic cells. Mutations along the yeast secretory pathway repress transcription of rRNA, tRNA, and ribosomal protein genes. Here, we show that these mutations also lead to a rapid and specific attenuation of translation initiation that occurs prior to the transcriptional inhibition of ribosomal components. Using distinct vesicular transport… CONTINUE READING
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