A membrane component of the endoplasmic reticulum that may be essential for protein translocation.

@article{Hartmann1989AMC,
  title={A membrane component of the endoplasmic reticulum that may be essential for protein translocation.},
  author={Enno Hartmann and Martin Wiedmann and Tom A Rapoport},
  journal={The EMBO journal},
  year={1989},
  volume={8 8},
  pages={2225-9}
}
We have purified a glycosylated, membrane-spanning protein of relative molecular mass approximately 34,000 (Mr approximately 34 K) from canine microsomes that appears to be essential for protein translocation across the endoplasmic reticulum (ER) as shown by the inhibitory action of antibodies directed against it and of monovalent Fab-fragments produced from them. The ER membrane contains at least as many molecules of the 34 K membrane protein as bound ribosomes. The protein can be detected… CONTINUE READING