A membrane-bound heparan sulfate proteoglycan that is transiently expressed on growing axons in the rat brain.

@article{Watanabe1996AMH,
  title={A membrane-bound heparan sulfate proteoglycan that is transiently expressed on growing axons in the rat brain.},
  author={Eiji Watanabe and Fumiko Matsui and Hiroomi Keino and Kenji Ono and Yukihiro Kushima and M. T. Noda and Atsuhiko Oohira},
  journal={Journal of neuroscience research},
  year={1996},
  volume={44 1},
  pages={84-96}
}
Monoclonal antibodies were raised to membrane-bound proteoglycans derived from rat brain and three monoclonal antibodies that recognized a 200-kDa heparan sulfate proteoglycan (designated H5-PG) with a core glycoprotein of 140 kDa were obtained. The expression of H5-PG was spatially and temporally regulated in the central nervous system. In the cerebellar cortex, H5-PG was associated mainly with the actively growing parallel fibers of granule cells. The expression was abruptly down-regulated in… CONTINUE READING