A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood.

@article{Neeves2008AMM,
  title={A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood.},
  author={Keith B. Neeves and Scott L. Diamond},
  journal={Lab on a chip},
  year={2008},
  volume={8 5},
  pages={701-9}
}
The flux of platelet agonists into flowing blood is a critical event in thrombosis and hemostasis. However, few in vitro methods exist for examining and controlling the role of platelet agonists on clot formation and stability under hemodynamic conditions. In this paper, we describe a membrane-based method for introducing a solute into flowing blood at a defined flux. The device consisted of a track-etched polycarbonate membrane reversibly sealed between two microfluidic channels; one channel… CONTINUE READING