A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export.

@article{Taura1998AMO,
  title={A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export.},
  author={Tetsuya Taura and Heike Krebber and Pamela A. Silver},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 13},
  pages={7427-32}
}
Yeast cells mutated in YRB2, which encodes a nuclear protein with similarity to other Ran-binding proteins, fail to export nuclear export signal (NES)-containing proteins including HIV Rev out of the nucleus. Unlike Xpo1p/Crm1p/exportin, an NES receptor, Yrb2p does not shuttle between the nucleus and the cytoplasm but instead remains inside the nucleus. However, by both biochemical and genetic criteria, Yrb2p interacts with Xpo1p and not with other members of the importin/karyopherin beta… CONTINUE READING
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Taura et al

  • M. Fornerod, J. van Deursen, +7 authors 807–816. 7432 Cell Biology
  • Proc. Natl. Acad. Sci. USA 95
  • 1998
1 Excerpt

Methods in Yeast Genetics: A Laboratory Course Manual (Cold

  • M. D. Rose, F. Winston, P. Hieter
  • 1990
1 Excerpt

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