A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer.

@article{Coppola2017AMA,
  title={A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer.},
  author={Stefano Coppola and Ilaria Carnevale and Erik H. J. Danen and Godefridus J. Peters and Thomas Schmidt and Yehuda G Assaraf and Elisa Giovannetti},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  year={2017},
  volume={31},
  pages={43-51}
}
Pancreatic ductal adenocarcinoma (PDAC) is a highly chemoresistant malignancy. This chemoresistant phenotype has been historically associated with genetic factors. Major biomedical research efforts were concentrated that resulted in the identification of subtypes characterized by specific genetic lesions and gene expression signatures that suggest important… CONTINUE READING