A mechanistic model on the role of "radially-running" collagen fibers on dissection properties of human ascending thoracic aorta.

@article{Pal2014AMM,
  title={A mechanistic model on the role of "radially-running" collagen fibers on dissection properties of human ascending thoracic aorta.},
  author={Siladitya Pal and Alkiviadis Tsamis and Salvatore Pasta and Antonio d'Amore and Thomas G. Gleason and David A. Vorp and Spandan Maiti},
  journal={Journal of biomechanics},
  year={2014},
  volume={47 5},
  pages={981-8}
}
Aortic dissection (AoD) is a common condition that often leads to life-threatening cardiovascular emergency. From a biomechanics viewpoint, AoD involves failure of load-bearing microstructural components of the aortic wall, mainly elastin and collagen fibers. Delamination strength of the aortic wall depends on the load-bearing capacity and local micro-architecture of these fibers, which may vary with age, disease and aortic location. Therefore, quantifying the role of fiber micro-architecture… CONTINUE READING
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