A mechanistic investigation into the irreversible protein binding and antigenicity of p-phenylenediamine.

@article{Jenkinson2009AMI,
  title={A mechanistic investigation into the irreversible protein binding and antigenicity of p-phenylenediamine.},
  author={Claire Jenkinson and Rosalind Jenkins and James L. Maggs and Neil R. Kitteringham and Maja Aleksic and Brian Kevin Park and Dean J Naisbitt},
  journal={Chemical research in toxicology},
  year={2009},
  volume={22 6},
  pages={1172-80}
}
Exposure to the skin sensitizer p-phenylenediamine (PPD) is associated with allergic contact dermatitis; however, the ability of PPD to modify protein has not been fully investigated. The aims of this study were to characterize the reactions of PPD and the structurally related chemical 2,5-dimethyl-1,4-benzoquinonediamine with model nucleophiles, a synthetic peptide (DS3) containing each of the naturally occurring amino acids and His-tagged glutathione-S-transferase pi (GSTP), and to explore… CONTINUE READING
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