A mechanistic explanation for the minimal impact of renal denervation on 24-h ambulatory blood pressure in SIMPLICITY HTN-3.


Explanations for the lack of significant lowering of 24-h ambulatory blood pressure following renal denervation in SYMPLICITY HTN-3 (Renal Denervation in Patients With Uncontrolled Hypertension) have been offered, including the unanticipated fall in ambulatory BP in the sham operated group, perhaps as a result of a Hawthorne effect or placebo effect (1… (More)
DOI: 10.1016/j.jacc.2014.10.076


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