A mechanistic approach to understanding species differences in felbamate bioactivation: relevance to drug-induced idiosyncratic reactions.

@article{Dieckhaus2000AMA,
  title={A mechanistic approach to understanding species differences in felbamate bioactivation: relevance to drug-induced idiosyncratic reactions.},
  author={Christine Dieckhaus and Thomas A. Miller and R. Duane Sofia and Timothy L. Macdonald},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2000},
  volume={28 7},
  pages={814-22}
}
In an attempt to understand the species-selective toxicity of felbamate (2-phenyl-1,3-propanediol dicarbamate, FBM), which is thought to result from bioactivation to 2-phenylpropenal, FBM metabolism was evaluated in rats and humans. The formation of 2-phenylpropenal was monitored by the amount of its mercapturates excreted in urine. The data show a relative 5-fold increase in mercapturate excretion in patient urine as a result of differences in metabolism through P450-, esterase-, and aldehyde… CONTINUE READING
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