A mechanistic analysis of the inoculum requirement for the cultivation of mammalian cells on microcarriers.

@article{Hu1985AMA,
  title={A mechanistic analysis of the inoculum requirement for the cultivation of mammalian cells on microcarriers.},
  author={Wei-Shou Hu and Johannes K.-H. Meier and Daniel I. C. Wang},
  journal={Biotechnology and bioengineering},
  year={1985},
  volume={27 5},
  pages={
          585-95
        }
}
For the cultivation of mammalian cells on microcarriers a minimum inoculum concentration is required to initiate cell attachment and subsequent cell growth. A critical cell number model has been proposed to elucidate the mechanism of the inoculum requirement. In this model it was hypothesized that after inoculation a critical number of cells per microcarrier is required for normal growth to occur; failure to acquire enough cells will impede cell growth. This critical cell number model was… CONTINUE READING

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