A mechanistic analysis of nitric oxide-induced cellular toxicity.

@article{Burney1997AMA,
  title={A mechanistic analysis of nitric oxide-induced cellular toxicity.},
  author={Sibte Burney and Snait Tamir and Annamaria Gal and Steven R Tannenbaum},
  journal={Nitric oxide : biology and chemistry},
  year={1997},
  volume={1 2},
  pages={130-44}
}
Nitric oxide (NO.)-induced toxicity was investigated in two different cell lines, Chinese hamster ovary (CHO-AA8) and human lymphoblastoid (TK6), over a range of NO. doses (0-9 mM) delivered for an exposure of 2 h. To determine both short-term and delayed effects leading to death, a range of assays was employed to decipher the major mechanisms of cytotoxicity. Examples of damage parameters measured in this study include inhibition of DNA synthesis, damage to mitochondria, loss of cell membrane… CONTINUE READING

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