A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding.

@article{Karim2006AMO,
  title={A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding.},
  author={M. Manjurul Karim and Yuri V. Svitkin and Avak Kahvejian and Gregory De Crescenzo and Mauro Costa-Mattioli and Nahum Sonenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 25},
  pages={9494-9}
}
The eukaryotic mRNA 3' poly(A) tail and the 5' cap cooperate to synergistically enhance translation. This interaction is mediated by the cap-binding protein eIF4E, the poly(A) binding protein (PABP), and eIF4G, a scaffolding protein that bridges between eIF4E and PABP to bring about the circularization of the mRNA. The translational repressor, Paip2 (PABP-interacting protein 2), inhibits translation by promoting the dissociation of PABP from poly(A). Here we report on the existence of an… CONTINUE READING

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Translational Control of Gene Expression

  • A. Sachs
  • 2000

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