A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.

@article{Bitzer2000AMO,
  title={A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.},
  author={Markus Bitzer and Gero von Gersdorff and Dongcai Liang and A Dominguez-Rosales and A. B. M. Rabiul Alam Beg and Marcos Rojkind and Erwin P. B{\"o}ttinger},
  journal={Genes & development},
  year={2000},
  volume={14 2},
  pages={187-97}
}
A number of pathogenic and proinflammatory stimuli, and the transforming growth factor-beta (TGF-beta) exert opposing activities in cellular and immune responses. Here we show that the RelA subunit of nuclear factor kappaB (NF-kappaB/RelA) is necessary for the inhibition of TGF-beta-induced phosphorylation, nuclear translocation, and DNA binding of SMAD signaling complexes by tumor necrosis factor-alpha (TNF-alpha). The antagonism is mediated through up-regulation of Smad7 synthesis and… CONTINUE READING
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