• Corpus ID: 74431556

A mechanism of resistance and mode of action for drugs against Plasmodium falciparum

  title={A mechanism of resistance and mode of action for drugs against Plasmodium falciparum},
  author={Anne E. Purfield},

In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum.

This study suggests that P. falciparum ring stages are less susceptible to DB75, and a milder and often statistically insignificant stage-specific trend was observed for piperaquine, whereas OZ277 and OZ401 were equally active against the erythrocytic parasite stages.

Enhancing Physicochemical Properties through Synthesis and Formulation of Piclamilast- and Lapatinib-Derived Analogs

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Table of



The global distribution of clinical episodes of Plasmodium falciparum malaria

It is estimated that there were 515 (range 300–660) million episodes of clinical P. falciparum malaria in 2002, up to 50% higher than those reported by the World Health Organization and 200% higher for areas outside Africa, reflecting the WHO's reliance upon passive national reporting for these countries.

Resistance to Antimalarials in Southeast Asia and Genetic Polymorphisms in pfmdr1

ABSTRACT Resistance to antimalarial drugs is a public health problem worldwide. Molecular markers for drug-resistant malaria, such as pfcrt and pfmdr1 polymorphisms, could serve as useful

Infectious diseases (2 volumes).

Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.

  • K. Werbovetz
  • Biology, Chemistry
    Current opinion in investigational drugs
  • 2006
The selectivity of diamidines against trypanosomes, Leishmania and Plasmodium is rationalized through mechanism-of-action studies and an overview of the antiprotozoal activities of newer diamidine and diamidine prodrugs is presented.

Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine.

It is suggested that most parasites observed at day 7 were probably recrudescences whereas most of those at day 28 were reinfections, implying a common genetic basis of resistance.

A molecular marker for chloroquine-resistant falciparum malaria.

  • D. Warhurst
  • Medicine
    The New England journal of medicine
  • 2001
The main ways to reduce morbidity and mortality are the use of insecticide-impregnated netting around the bed and chemoprophylaxis for specific groups at increased risk, such as nonimmune travelers to an area where malaria is endemic, pregnant women,1 and children with sickle cell anemia.

Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso.

The results clarify the key roles of a small number of mutations in P. falciparum resistance to SP and AQ in west Africa and show significant increases in the prevalence of the same mutations in new infections that presented after therapy.

Uncomplicated malaria.

All symptoms and signs of uncomplicated malaria are non-specific, as shared with other febrile conditions, and can occur early or later in the course of the disease. In endemic areas, the presence of