In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum.
- MedicineThe Journal of antimicrobial chemotherapy
This study suggests that P. falciparum ring stages are less susceptible to DB75, and a milder and often statistically insignificant stage-specific trend was observed for piperaquine, whereas OZ277 and OZ401 were equally active against the erythrocytic parasite stages.
Enhancing Physicochemical Properties through Synthesis and Formulation of Piclamilast- and Lapatinib-Derived Analogs
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Pentamidine uptake and resistance in pathogenic protozoa: past, present and future.
- BiologyTrends in parasitology
Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel.
- BiologyThe Journal of biological chemistry
The global distribution of clinical episodes of Plasmodium falciparum malaria
It is estimated that there were 515 (range 300–660) million episodes of clinical P. falciparum malaria in 2002, up to 50% higher than those reported by the World Health Organization and 200% higher for areas outside Africa, reflecting the WHO's reliance upon passive national reporting for these countries.
Resistance to Antimalarials in Southeast Asia and Genetic Polymorphisms in pfmdr1
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
ABSTRACT Resistance to antimalarial drugs is a public health problem worldwide. Molecular markers for drug-resistant malaria, such as pfcrt and pfmdr1 polymorphisms, could serve as useful…
Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.
- Biology, ChemistryCurrent opinion in investigational drugs
The selectivity of diamidines against trypanosomes, Leishmania and Plasmodium is rationalized through mechanism-of-action studies and an overview of the antiprotozoal activities of newer diamidine and diamidine prodrugs is presented.
Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine.
It is suggested that most parasites observed at day 7 were probably recrudescences whereas most of those at day 28 were reinfections, implying a common genetic basis of resistance.
A molecular marker for chloroquine-resistant falciparum malaria.
- MedicineThe New England journal of medicine
The main ways to reduce morbidity and mortality are the use of insecticide-impregnated netting around the bed and chemoprophylaxis for specific groups at increased risk, such as nonimmune travelers to an area where malaria is endemic, pregnant women,1 and children with sickle cell anemia.
Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso.
- MedicineThe American journal of tropical medicine and hygiene
The results clarify the key roles of a small number of mutations in P. falciparum resistance to SP and AQ in west Africa and show significant increases in the prevalence of the same mutations in new infections that presented after therapy.
- MedicineCurrent topics in microbiology and immunology
All symptoms and signs of uncomplicated malaria are non-specific, as shared with other febrile conditions, and can occur early or later in the course of the disease. In endemic areas, the presence of…