A mechanism of nitric oxide-induced surfactant dysfunction.

  title={A mechanism of nitric oxide-induced surfactant dysfunction.},
  author={Mikko K. Hallman and Krisiina Bry and Urpo Lappalainen},
  journal={Journal of applied physiology},
  volume={80 6},
Inhaled nitric oxide (NO) may modify surfactant either by interacting with the surfactant complex or by changing the capacity of the proteins of the epithelial lining fluid to inhibit the surface activity. Natural surfactant was exposed to NO (80 parts/million) in air in vitro while the gas-liquid surface was cycled. In the presence or absence of oxidants… CONTINUE READING