A mechanism of acquiring temozolomide resistance during transformation of atypical prolactinoma into prolactin-producing pituitary carcinoma: case report.

@article{Murakami2011AMO,
  title={A mechanism of acquiring temozolomide resistance during transformation of atypical prolactinoma into prolactin-producing pituitary carcinoma: case report.},
  author={Mineko Murakami and Akiko Mizutani and S. Asano and Hideki Katakami and Yoshinori Ozawa and Kazuto Yamazaki and Yasuo Ishida and Koji Takano and Hiroko Okinaga and Akira Matsuno},
  journal={Neurosurgery},
  year={2011},
  volume={68 6},
  pages={E1761-7; discussion E1767}
}
BACKGROUND AND IMPORTANCE The case presented here describes the clinical evolution of a pituitary carcinoma from an atypical prolactinoma after temozolomide (TMZ) treatment. The mechanism of acquisition of TMZ resistance was analyzed. CLINICAL PRESENTATION A 60-year-old woman with atypical prolactinoma had been treated for 7 years with multiple therapies, including dopamine agonists, surgical intervention (5 times), conventional radiotherapy, and radiosurgery. The patient deteriorated as a… CONTINUE READING
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