A mechanism intrinsic to the vesicle fusion machinery determines fast and slow transmitter release at a large CNS synapse.

@article{Wlfel2007AMI,
  title={A mechanism intrinsic to the vesicle fusion machinery determines fast and slow transmitter release at a large CNS synapse.},
  author={Markus W{\"o}lfel and Xuelin Lou and Ralf Schneggenburger},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 12},
  pages={3198-210}
}
Heterogeneity of release probability p between vesicles in the readily releasable pool (RRP) is expected to strongly influence the kinetics of depression at synapses, but the underlying mechanism(s) are not well understood. To test whether differences in the intrinsic Ca2+ sensitivity of vesicle fusion might cause heterogeneity of p, we made presynaptic Ca2+-uncaging measurements at the calyx of Held and analyzed the time course of transmitter release by EPSC deconvolution. Ca2+ uncaging, which… CONTINUE READING

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