A mechanism for the synergistic antimalarial action of atovaquone and proguanil.

  title={A mechanism for the synergistic antimalarial action of atovaquone and proguanil.},
  author={Indresh K. Srivastava and Akhil B. Vaidya},
  journal={Antimicrobial agents and chemotherapy},
  volume={43 6},
A combination of atovaquone and proguanil has been found to be quite effective in treating malaria, with little evidence of the emergence of resistance when atovaquone was used as a single agent. We have examined possible mechanisms for the synergy between these two drugs. While proguanil by itself had no effect on electron transport or mitochondrial membrane potential (DeltaPsim), it significantly enhanced the ability of atovaquone to collapse DeltaPsim when used in combination. This… CONTINUE READING
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