A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

@article{Lisman1989AMF,
  title={A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.},
  author={J Lisman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 23},
  pages={9574-8}
}
  • J Lisman
  • Published 1989 in
    Proceedings of the National Academy of Sciences…
In a previous paper, a model was presented showing how the group of Ca2+/calmodulin-dependent protein kinase II molecules contained within a postsynaptic density could stably store a graded synaptic weight. This paper completes the model by showing how bidirectional control of synaptic weight could be achieved. It is proposed that the quantitative level of the activity-dependent rise in postsynaptic Ca2+ determines whether the synaptic weight will increase or decrease. It is further proposed… CONTINUE READING
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