A mechanism for plus-strand transfer enhancement by the HIV-1 nucleocapsid protein during reverse transcription.

@article{Johnson2000AMF,
  title={A mechanism for plus-strand transfer enhancement by the HIV-1 nucleocapsid protein during reverse transcription.},
  author={Philip E. Johnson and Ryan B. Turner and Z R Wu and L Hairston and Jianhui Guo and Judith G Levin and Michael F Summers},
  journal={Biochemistry},
  year={2000},
  volume={39 31},
  pages={9084-91}
}
The HIV-1 nucleocapsid protein (NC) functions as a nucleic acid chaperone during the plus-strand transfer step in reverse transcription by facilitating annealing of the primer binding site (PBS) sequence in the short plus-strand strong-stop DNA fragment [(+) SSDNA] to a complementary site located near the 3' end of the minus-strand DNA [(-) PBS DNA]. To investigate the mechanism by which NC performs this function, we have prepared an 18-nucleotide (-) PBS DNA for nuclear magnetic resonance (NMR… CONTINUE READING
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RetroViruses, Cold Spring Harbor Laboratory Press, Plainview, NY

  • J. M. Coffin, S. H. Hughes, H. E. Varmus
  • 1997
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