A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters

  title={A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters},
  author={Lina Malinauskaite and Matthias Quick and Linda Reinhard and Joseph A Lyons and Hideaki Yano and Jonathan A. Javitch and Poul Nissen},
  journal={Nature Structural &Molecular Biology},
Neurotransmitter/sodium symporters (NSSs) terminate synaptic signal transmission by Na+-dependent reuptake of released neurotransmitters. Key conformational states have been reported for the bacterial homolog LeuT and an inhibitor-bound Drosophila dopamine transporter. However, a coherent mechanism of Na+-driven transport has not been described. Here, we present two crystal structures of MhsT, an NSS member from Bacillus halodurans, in occluded inward-facing states with bound Na+ ions and L… CONTINUE READING
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