A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters

@article{Malinauskaite2014AMF,
  title={A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters},
  author={Lina Malinauskaite and Matthias Quick and Linda Reinhard and Joseph A Lyons and Hideaki Yano and Jonathan A. Javitch and Poul Nissen},
  journal={Nature Structural &Molecular Biology},
  year={2014},
  volume={21},
  pages={1006-1012}
}
Neurotransmitter/sodium symporters (NSSs) terminate synaptic signal transmission by Na+-dependent reuptake of released neurotransmitters. Key conformational states have been reported for the bacterial homolog LeuT and an inhibitor-bound Drosophila dopamine transporter. However, a coherent mechanism of Na+-driven transport has not been described. Here, we present two crystal structures of MhsT, an NSS member from Bacillus halodurans, in occluded inward-facing states with bound Na+ ions and L… CONTINUE READING
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Crystal structure of a eukaryotic phosphate transporter

B. P. Pedersen
Nature • 2013

Improvement of molecular-replacement models with Sculptor

Acta crystallographica. Section D, Biological crystallography • 2011

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