A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.

@article{Saito1993AMF,
  title={A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.},
  author={Kuniaki Saito and John S. Crowley and Sanford P. Markey and Melvyn P. Heyes},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 21},
  pages={15496-503}
}
Mechanisms for increased levels of quinolinic acid (QUIN) following systemic immune stimulation were investigated. In gerbils, systemic administration of pokeweed mitogen (PWM) increased plasma and cerebrospinal fluid QUIN levels, while plasma kynurenic acid levels were decreased and cerebrospinal fluid kynurenic acid levels were unchanged. PWM also increased the QUIN concentrations of brain and systemic tissues. In slices of spleen, lung, liver, duodenum, and kidney, PWM caused marked… CONTINUE READING
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