A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients.

Abstract

AIMS This study investigated the pharmacokinetics of cyclophosphamide (CP) and its main metabolite 4-hydroxycyclophosphamide (4-OH-CP) in patients with breast cancer undergoing high dose chemotherapy prior to autologous stem cell transplantation. An enzyme turn-over model was also developed to study the time course of cyclophosphamide induction. METHODS… (More)

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@article{Hassan1999AMP, title={A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients.}, author={Md Salleh Hassan and Ulrika S H Svensson and P Ljungman and B B Bj{\"{o}rkstrand and H{\aa}kan Olsson and Margareta Bielenstein and Mohamed Saber Abdel-Rehim and C Nilsson and Madelene Johansson and M O Karlsson}, journal={British journal of clinical pharmacology}, year={1999}, volume={48 5}, pages={669-77} }