A means to a DNA end: the many roles of Ku

@article{Downs2004AMT,
  title={A means to a DNA end: the many roles of Ku},
  author={Jessica A Downs and Stephen P. Jackson},
  journal={Nature Reviews Molecular Cell Biology},
  year={2004},
  volume={5},
  pages={367-378}
}
Key PointsKu is a heterodimer composed of two subunits — Ku70 and Ku80 — that binds to DNA ends in a sequence-independent manner. From crystallographic studies, we know that it is shaped like an asymmetric ring, encircling the DNA but also leaving parts of the helix exposed.Ku is found throughout eukaryotic evolution and in higher eukaryotes is associated with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to form the DNA-PK holoenzyme. Recently, Ku homologues have also been… CONTINUE READING
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