A maximum likelihood approach to two-dimensional crystals.

  title={A maximum likelihood approach to two-dimensional crystals.},
  author={Xiangyan Zeng and Henning Stahlberg and Nikolaus Grigorieff},
  journal={Journal of structural biology},
  volume={160 3},
Maximum likelihood (ML) processing of transmission electron microscopy images of protein particles can produce reconstructions of superior resolution due to a reduced reference bias. We have investigated a ML processing approach to images centered on the unit cells of two-dimensional (2D) crystal images. The implemented software makes use of the predictive lattice node tracking in the MRC software, which is used to window particle stacks. These are then noise-whitened and subjected to ML… CONTINUE READING
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