A matter of life and death: cell wall homeostasis and the WalKR (YycGF) essential signal transduction pathway.

@article{Dubrac2008AMO,
  title={A matter of life and death: cell wall homeostasis and the WalKR (YycGF) essential signal transduction pathway.},
  author={Sarah Dubrac and Paola Bisicchia and Kevin M Devine and Tarek Msadek},
  journal={Molecular microbiology},
  year={2008},
  volume={70 6},
  pages={1307-22}
}
The WalK/WalR (aka YycG/YycF) two-component system (TCS), originally identified in Bacillus subtilis, is very highly conserved and specific to low G+C Gram-positive bacteria, including a number of important pathogens. An unusual feature is that this system is essential for viability in most of these bacteria. Recent studies have revealed conserved functions for this system, defining this signal transduction pathway as a crucial regulatory system for cell wall metabolism, that we have… CONTINUE READING

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