A mathematical tool for exploring the dynamics of biological networks.

@article{Barbano2007AMT,
  title={A mathematical tool for exploring the dynamics of biological networks.},
  author={Paolo Emilio Barbano and Marina Spivak and Marc Flajolet and Angus C. Nairn and Paul Greengard and Leslie Greengard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 49},
  pages={
          19169-74
        }
}
We have developed a mathematical approach to the study of dynamical biological networks, based on combining large-scale numerical simulation with nonlinear "dimensionality reduction" methods. Our work was motivated by an interest in the complex organization of the signaling cascade centered on the neuronal phosphoprotein DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of molecular weight 32,000). Our approach has allowed us to detect robust features of the system in the presence of noise… CONTINUE READING

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