• Corpus ID: 3218426

A mathematical study of CD8+ T cell responses calibrated with human data

  title={A mathematical study of CD8+ T cell responses calibrated with human data},
  author={John Paul Gosling and Sheeja M. Krishnan and Grant D. Lythe and Benjamin M. Chain and C Mackay and Carmen Molina-Par'is},
  journal={arXiv: Cell Behavior},
Complete understanding of the mechanisms regulating the proliferation and differentiation that takes place during human immune CD8+ T cell responses is still lacking. Human clinical data is usually limited to blood cell counts, yet the initiation of these responses occurs in the draining lymph nodes; antigen-specific effector and memory CD8+ T cells generated in the lymph nodes migrate to those tissues where they are required. We use approximate Bayesian computation with deterministic… 
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