• Corpus ID: 3218426

A mathematical study of CD8+ T cell responses calibrated with human data

@article{Gosling2018AMS,
  title={A mathematical study of CD8+ T cell responses calibrated with human data},
  author={John Paul Gosling and Sheeja M. Krishnan and Grant D. Lythe and Benjamin M. Chain and C Mackay and Carmen Molina-Par'is},
  journal={arXiv: Cell Behavior},
  year={2018}
}
Complete understanding of the mechanisms regulating the proliferation and differentiation that takes place during human immune CD8+ T cell responses is still lacking. Human clinical data is usually limited to blood cell counts, yet the initiation of these responses occurs in the draining lymph nodes; antigen-specific effector and memory CD8+ T cells generated in the lymph nodes migrate to those tissues where they are required. We use approximate Bayesian computation with deterministic… 
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References

SHOWING 1-10 OF 96 REFERENCES
The memory of a killer T cell: models of CD8+ T cell differentiation
TLDR
Recent quantitative studies that support different hypotheses of CD8+ T‐cell differentiation are reviewed to help clarify the timing and mechanisms underlying the differentiation of naive cells into effector cells and memory cells.
Heterogeneous Differentiation Patterns of Individual CD8+ T Cells
TLDR
It is demonstrated that, even for T cells bearing identical T cell receptors, both clonal expansion and differentiation patterns are heterogeneous, and individual naïve T lymphocytes contributed differentially to short- and long-term protection, as revealed by participation of their progeny during primary versus recall infections.
Harnessing the Heterogeneity of T Cell Differentiation Fate to Fine-Tune Generation of Effector and Memory T Cells
TLDR
A multi-organ (multi-compartment) model is developed to elaborate mechanisms occurring within and between two important physiological compartments, lymph nodes and blood, to determine how immune cell dynamics are controlled.
Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines
TLDR
By combining antigenic stimulation and T cell receptor deep sequencing, this work finds that human pathogen- and vaccine-specific T helper 1 (TH1), TH2, and TH17 memory cells have different frequencies but comparable diversity and comprise not only clones polarized toward a single fate, but also clones whose progeny have acquired multiple fates.
Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection.
TLDR
Initial endogenous precursor frequencies were surprisingly diverse and not only regulated initial immune response characteristics but also controlled memory CD8+ T cell lineage decisions.
Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines.
TLDR
The results show that both vaccines generated a brisk primary effector CD8(+) T cell response of substantial magnitude that could be readily quantitated with a simple set of four phenotypic markers.
Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD4+ and CD8+ T cells
TLDR
An unexpectedly asymmetric role for MHC interactions in controlling CD4+ vs. CD8+ T lymphocyte recirculation is revealed, as well as distinct contributions of T cell receptor (TCR)-independent factors to the LN transit time, exposing the divergent surveillance strategies used by the two lymphocyte populations in scanning for foreign antigen.
Models of CD8+ responses: 1. What is the antigen-independent proliferation program.
TLDR
Simple mathematical models are constructed which incorporate antigen-independent proliferation and differentiation of CD8 cells during acute infections and suggest that the program is not completely defined by the initial encounter of T cell with antigen but may be augmented by exposure to antigen in a brief window shortly after infection.
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets.
TLDR
A unique analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors is presented, revealing tissue-intrinsic compartmentalization of naive, effector, and memory subsets conserved between diverse individuals.
Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life
TLDR
The results reveal that the distribution and tissue residence of naive, central, and effector memory, and terminal effector subsets is contingent on both their differentiation state and tissue localization, supporting distinct pathways for human T cell fate determination and homeostasis.
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