A mathematical modelling study of epiphyseal cartilage calcification.

  title={A mathematical modelling study of epiphyseal cartilage calcification.},
  author={Graeme K. Hunter and Sabine Bader},
  journal={Journal of theoretical biology},
  volume={138 2},
Recent studies in this laboratory have suggested that proteoglycan may function as a Ca ion-exchanger in the calcification of epiphyseal growth plate cartilage. Specifically, it has been proposed that phosphate liberated from hypertrophic chondrocytes may displace calcium ions bound to the anionic groups of proteoglycans, thereby raising the Ca x PO4 activity product above the threshold for precipitation of hydroxyapatite. In order to determine whether this mechanism is quantitatively feasible… CONTINUE READING