A mathematical model quantifying GnRH-induced LH secretion from gonadotropes.

@article{Blum2000AMM,
  title={A mathematical model quantifying GnRH-induced LH secretion from gonadotropes.},
  author={J. Blum and M. Reed and J. Janovick and P. Conn},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2000},
  volume={278 2},
  pages={
          E263-72
        }
}
  • J. Blum, M. Reed, +1 author P. Conn
  • Published 2000
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
A mathematical model is developed to investigate the rate of release of luteinizing hormone (LH) from pituitary gonadotropes in response to short pulses of gonadotropin-releasing hormone (GnRH). The model includes binding of the hormone to its receptor, dimerization, interaction with a G protein, production of inositol 1,4, 5-trisphosphate, release of Ca(2+) from the endoplasmic reticulum, entrance of Ca(2+) into the cytosol via voltage-gated membrane channels, pumping of Ca(2+) out of the… Expand
41 Citations
A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH
  • 40
  • PDF
A Mathematical Model for the Actions of Activin, Inhibin, and Follistatin on Pituitary Gonadotrophs
  • 16
  • PDF
A mathematical model of the human menstrual cycle for the administration of GnRH analogues.
  • 42
  • PDF
Negative Feedback Governs Gonadotrope Frequency-Decoding of Gonadotropin Releasing Hormone Pulse-Frequency
  • 50
  • Highly Influenced
  • PDF
A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming
  • 6
  • PDF
Age-dependent regression analysis of male gonadal axis.
  • D. M. Keenan, J. Veldhuis
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2009
  • 13
  • PDF
Mathematical modeling of perifusion cell culture experiments on GnRH signaling.
  • 1
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Generation and amplification of the cytosolic calcium signal during secretory responses to gonadotropin-releasing hormone.
  • 21
  • Highly Influential
Gonadotropin-releasing hormone stimulation of luteinizing hormone release: A ligand-receptor-effector model.
  • J. Blum, P. Conn
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1982
  • 46
  • PDF
Novel Aspects of GnRH‐Induced Intracellular Signaling and Secretion in Pituitary Gonadotrophs
  • 96
Biphasic regulation of the gonadotropin-releasing hormone receptor by receptor microaggregation and intracellular Ca2+ levels.
  • 91
A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone.
  • 174
  • PDF
GnRH-induced calcium and current oscillations in gonadotrophs
  • 22
...
1
2
3
4
5
...