A mathematical model of tumour self-seeding reveals secondary metastatic deposits as drivers of primary tumour growth

@article{Scott2013AMM,
  title={A mathematical model of tumour self-seeding reveals secondary metastatic deposits as drivers of primary tumour growth},
  author={J. Scott and D. Basanta and A. Anderson and P. Gerlee},
  journal={Journal of The Royal Society Interface},
  year={2013},
  volume={10}
}
Two models of circulating tumour cell (CTC) dynamics have been proposed to explain the phenomenon of tumour ‘self-seeding’, whereby CTCs repopulate the primary tumour and accelerate growth: primary seeding, where cells from a primary tumour shed into the vasculature and return back to the primary themselves; and secondary seeding, where cells from the primary first metastasize into a secondary tissue and form microscopic secondary deposits, which then shed cells into the vasculature returning… Expand
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