A mathematical model of tumour self-seeding reveals secondary metastatic deposits as drivers of primary tumour growth
@article{Scott2013AMM, title={A mathematical model of tumour self-seeding reveals secondary metastatic deposits as drivers of primary tumour growth}, author={J. Scott and D. Basanta and A. Anderson and P. Gerlee}, journal={Journal of The Royal Society Interface}, year={2013}, volume={10} }
Two models of circulating tumour cell (CTC) dynamics have been proposed to explain the phenomenon of tumour ‘self-seeding’, whereby CTCs repopulate the primary tumour and accelerate growth: primary seeding, where cells from a primary tumour shed into the vasculature and return back to the primary themselves; and secondary seeding, where cells from the primary first metastasize into a secondary tissue and form microscopic secondary deposits, which then shed cells into the vasculature returning… Expand
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