A mathematical model of the sleep/wake cycle.

  title={A mathematical model of the sleep/wake cycle.},
  author={M. J. Rempe and Janet Best and David Terman},
  journal={Journal of mathematical biology},
  volume={60 5},
We present a biologically-based mathematical model that accounts for several features of the human sleep/wake cycle. These features include the timing of sleep and wakefulness under normal and sleep-deprived conditions, ultradian rhythms, more frequent switching between sleep and wakefulness due to the loss of orexin and the circadian dependence of several sleep measures. The model demonstrates how these features depend on interactions between a circadian pacemaker and a sleep homeostat and… CONTINUE READING