A mathematical model of the hsp70 regulation in the cell.

@article{Peper1998AMM,
  title={A mathematical model of the hsp70 regulation in the cell.},
  author={Abraham Peper and Cornelis A. Grimbergen and Jos A. E. Spaan and Jan E. M. Souren and Roeland J van Wijk},
  journal={International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group},
  year={1998},
  volume={14 1},
  pages={97-124}
}
A mathematical model of the regulation process of the heat shock protein hsp70 in the cell is presented. The model describes the damaging effect of elevated temperature on proteins; the interaction of free hsp70 with injured proteins and its chaperone role in nascent protein translation; the relation between the amount of free hsp70 and the formation of the activated trimer form of the heat shock factor protein (HSF); the binding of activated HSF with the heat shock elements on the DNA; the… CONTINUE READING

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