A mathematical model of reward-mediated learning in drug addiction.

@article{Chou2022AMM,
  title={A mathematical model of reward-mediated learning in drug addiction.},
  author={Tom Chou and Maria R. D’Orsogna},
  journal={Chaos},
  year={2022},
  volume={32 2},
  pages={
          021102
        }
}
Substances of abuse are known to activate and disrupt neuronal circuits in the brain reward system. We propose a simple and easily interpretable dynamical systems model to describe the neurobiology of drug addiction that incorporates the psychiatric concepts of reward prediction error, drug-induced incentive salience, and opponent process theory. Drug-induced dopamine releases activate a biphasic reward response with pleasurable, positive "a-processes" (euphoria, rush) followed by unpleasant… 

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References

SHOWING 1-10 OF 73 REFERENCES
Drug Addiction, Dysregulation of Reward, and Allostasis
A neurocomputational hypothesis for nicotine addiction.
TLDR
It is shown that an opponent process enhanced by persistent nicotine-taking renders self-administration rigid and habitual by inhibiting the learning process, resulting in long-term impairments in the absence of the drug.
Dynorphin and the pathophysiology of drug addiction.
Molecular mechanisms of drug reinforcement and addiction.
TLDR
Drug reinforcement is a form of behavioral plasticity in which behavioral changes occur in response to acute exposure to a reinforcing drug, and the addicted state are both characterized by an increase in drug-seeking behavior.
Individual differences in the neuropsychopathology of addiction
TLDR
Characterization of the neuropsychological mechanisms that underlie individual differences in addiction-like behaviors is the key to understanding the mechanisms of addiction and development of personalized pharmacotherapy.
The Dopamine Hypothesis of Drug Addiction and Its Potential Therapeutic Value
  • M. Diana
  • Biology, Psychology
    Front. Psychiatry
  • 2011
TLDR
Its anatomo-physiological rationale as a possible therapeutic aid in alcoholics and other addicts will be described and proposed as a theoretical framework to be subjected to experimental testing in human addicts.
Imbalanced Decision Hierarchy in Addicts Emerging from Drug-Hijacked Dopamine Spiraling Circuit
TLDR
It is shown that addictive drugs gradually produce a motivational bias toward drug-seeking at low-level habitual decision processes, despite the low abstract cognitive valuation of this behavior, which sets the stage for a view of addiction as a pathology of hierarchical decision-making processes.
Reward and Aversion.
  • Hailan Hu
  • Psychology, Biology
    Annual review of neuroscience
  • 2016
TLDR
This review aims to outline historic perspectives and new insights into the functions of DA and 5-HT systems in coding the distinct components of rewards, and highlights recent advances in neural circuit studies enabled by new technologies, such as cell-type-specific electrophysiology and tracing, and optogenetics-based behavioral manipulation.
...
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