A mathematical model of reward-mediated learning in drug addiction.

  title={A mathematical model of reward-mediated learning in drug addiction.},
  author={Tom Chou and Maria R. D’Orsogna},
  volume={32 2},
Substances of abuse are known to activate and disrupt neuronal circuits in the brain reward system. We propose a simple and easily interpretable dynamical systems model to describe the neurobiology of drug addiction that incorporates the psychiatric concepts of reward prediction error, drug-induced incentive salience, and opponent process theory. Drug-induced dopamine releases activate a biphasic reward response with pleasurable, positive "a-processes" (euphoria, rush) followed by unpleasant… 

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