A mathematical model of metabolic insulin signaling pathways.

@article{Sedaghat2002AMM,
  title={A mathematical model of metabolic insulin signaling pathways.},
  author={Ahmad R Sedaghat and Arthur Sherman and Michael J. Quon},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={283 5},
  pages={E1084-101}
}
We develop a mathematical model that explicitly represents many of the known signaling components mediating translocation of the insulin-responsive glucose transporter GLUT4 to gain insight into the complexities of metabolic insulin signaling pathways. A novel mechanistic model of postreceptor events including phosphorylation of insulin receptor substrate-1, activation of phosphatidylinositol 3-kinase, and subsequent activation of downstream kinases Akt and protein kinase C-zeta is coupled with… CONTINUE READING
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