A mathematical model of luteinizing hormone release from ovine pituitary cells in perifusion.

  title={A mathematical model of luteinizing hormone release from ovine pituitary cells in perifusion.},
  author={K. Heinze and R. Keener and A. R. Midgley},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={275 6},
We model the effect of gonadotropin-releasing hormone (GnRH) on the production of luteinizing hormone (LH) by the ovine pituitary. GnRH, released by the hypothalamus, stimulates the secretion of LH from the pituitary. If stimulus pulses are regular, LH response will follow a similar pattern. However, during application of GnRH at high frequencies or concentrations or with continuous application, the pituitary delivers a decreased release of LH (termed desensitization). The proposed mathematical… Expand
24 Citations
A Mathematical Model for the Actions of Activin, Inhibin, and Follistatin on Pituitary Gonadotrophs
  • 16
  • PDF
A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH
  • 40
  • PDF
A mathematical model of the human menstrual cycle for the administration of GnRH analogues.
  • 42
  • Highly Influenced
  • PDF
A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming
  • 6
  • PDF
Numerical and Discrete Modeling of Reproductive Endocrinological Networks
A simple mathematical model of the bovine estrous cycle: follicle development and endocrine interactions.
  • 24
  • PDF


Compartmentalization of luteinizing hormone pools: Dynamics of gonadotropin releasing hormone action in superfused pituitary cells
  • 63
Two pools of luteinizing hormone in the human pituitary: evidence from constant administration of luteinizing hormone-releasing hormone.
  • 144
  • PDF
Desensitization to gonadotropin-releasing hormone observed in superfused pituitary cells on Cytodex beads.
  • 161
Microaggregation of the gonadotropin-releasing hormone-receptor: relation to gonadotrope desensitization.
  • 44
Varying the patterns and concentrations of gonadotrophin-releasing hormone stimulation does not alter the ratio of LH and FSH released from perifused sheep pituitary cells.
  • 17
  • Highly Influential
The estradiol-induced surge of gonadotropin-releasing hormone in the ewe.
  • 310